The organization of the human striatum estimated by intrinsic functional connectivity.
نویسندگان
چکیده
The striatum is connected to the cerebral cortex through multiple anatomical loops that process sensory, limbic, and heteromodal information. Tract-tracing studies in the monkey reveal that these corticostriatal connections form stereotyped patterns in the striatum. Here the organization of the striatum was explored in the human with resting-state functional connectivity MRI (fcMRI). Data from 1,000 subjects were registered with nonlinear deformation of the striatum in combination with surface-based alignment of the cerebral cortex. fcMRI maps derived from seed regions placed in the foot and tongue representations of the motor cortex yielded the expected inverted somatotopy in the putamen. fcMRI maps derived from the supplementary motor area were located medially to the primary motor representation, also consistent with anatomical studies. The topography of the complete striatum was estimated and replicated by assigning each voxel in the striatum to its most strongly correlated cortical network in two independent groups of 500 subjects. The results revealed at least five cortical zones in the striatum linked to sensorimotor, premotor, limbic, and two association networks with a topography globally consistent with monkey anatomical studies. The majority of the human striatum was coupled to cortical association networks. Examining these association networks further revealed details that fractionated the five major networks. The resulting estimates of striatal organization provide a reference for exploring how the striatum contributes to processing motor, limbic, and heteromodal information through multiple large-scale corticostriatal circuits.
منابع مشابه
The Organization of the Human Striatum Estimated 1 By Intrinsic Functional Connectivity 2 3 Eun
The Organization of the Human Striatum Estimated 1 By Intrinsic Functional Connectivity 2 3 Eun Young Choi, B.T. Thomas Yeo, and Randy L. Buckner 4 5 Harvard University Department of Psychology, Center for Brain Science, Cambridge, 6 MA; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, 7 Massachusetts General Hospital, Charlestown, MA; Neuroscience and Behavioral Di...
متن کاملUnravelling the Intrinsic Functional Organization of the Human Striatum: A Parcellation and Connectivity Study Based on Resting-State fMRI
As the main input hub of the basal ganglia, the striatum receives projections from the cerebral cortex. Many studies have provided evidence for multiple parallel corticostriatal loops based on the structural and functional connectivity profiles of the human striatum. A recent resting-state fMRI study revealed the topography of striatum by assigning each voxel in the striatum to its most strongl...
متن کاملThe Organization of the Human Cerebellum Estimated 1 By Intrinsic Functional Connectivity
The Organization of the Human Cerebellum Estimated 1 By Intrinsic Functional Connectivity 2 3 Randy L. Buckner, Fenna M. Krienen, Angela Castellanos, Julio C. Diaz, 4 and B. T. Thomas Yeo 5 6 Howard Hughes Medical Institute, Cambridge, MA; Harvard University Department of 7 Psychology, Center for Brain Science, Cambridge, MA; Department of Psychiatry, 8 Massachusetts General Hospital, Boston, M...
متن کاملBrain Functional Connectivity Changes During Learning of Time Discrimination
The human brain is a complex system consist of connected nerve cells that adapts with and learn from the environment by changing its regional activities. Synchrony between these regional activities called functional network changes during the life, and with learning of new skills. Time perception and interval discrimination are among the most necessary skills for the human being to perceive mot...
متن کاملEvaluation of Model-Based Methods in Estimating Dynamic Functional Connectivity of Brain Regions
Today, neuroscientists are interested in discovering human brain functions through brain networks. In this regard, the evaluation of dynamic changes in functional connectivity of the brain regions by using functional magnetic resonance imaging data has attracted their attention. In this paper, we focus on two model-based approaches, called the exponential weighted moving average model and the d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of neurophysiology
دوره 108 8 شماره
صفحات -
تاریخ انتشار 2012